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However, in Korea, regulations on the use of urshiol-removed lacquer tree extract have been relaxed since 2004. The lacquer sap contains various active ingredients such as urushiol, fisetin, fustin, and butein, but urushiol is an allergic ingredient and causes connection dermatitis, so the range of use of lacquer was very limited. The sap that comes out of a wound on the bark of a lacquer tree is called lacquer, and lacquer has been widely used for food and medicine since ancient times. Rhus verniciflua Stokes (RVS) is known by the common name lacquer tree, which is an Asian tree species of the Anacardiaceae family and cultivated in regions of China, Japan, and Korea. But, since there is no registered drug for the treatment of NAFLD, diet and exercise are considered very important treatment methods. Therefore, prevention and treatment in subjects with NAFLD are important. Subjects with NAFLD have a higher mortality rate from liver diseases or other causes, and the risk of cardiovascular disease and chronic kidney disease is also increased compared to that in subjects without NAFLD. Registered on 2 December 2020īased on the Korea National Health and Nutrition Survey data from 1998 to 2017, a recent study reported that the prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing rapidly, especially in men, estimating that NAFLD would reach 44% by 2035. The study protocol was registered in the Clinical Research Information Service (CRIS: ) under number KCT0005687. In our study, we did not confirm the significance in liver function parameters and serum lipid profiles. There was no significant difference when comparing the change values of liver disease-related parameters and serum lipid profiles in between groups. The effects between the test and control groups were compared using the Mann-Whitney U test and independent t-test, and the difference between baseline and follow-up values was compared using Wilcoxon rank-sum test and paired t-test. Both before and after FRVE intake, anthropometric parameters, liver function-related parameters, and clinical laboratory parameters were measured. A 1:1 randomization of control and test was performed using computer-generated randomization. The control group ( n = 40) consumed two placebo pills (main component: lactose 627.0 mg) once daily. For 12 weeks, the test group ( n = 39) consumed two capsules of FRVE (main components: fustin 129 mg and fisetin 59 mg) once daily. An aqueous extract of fermented Rhus verniciflua Stokes that was filtered and fermented was prepared. MethodsĪ randomized, double-blind, placebo-controlled study was conducted among 79 subjects. We investigated the effects of FRVE intake for 12 weeks on liver disease-related parameters and serum lipid profiles in Korean adults. However, it remains unclear whether there is an effect of FRVE on liver disease-related parameters and serum lipid levels in humans.
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Fermented Rhus verniciflua Stokes extract (FRVE) reported an anti-hepatic lipidemic property mediated by the upregulation of AMP-activated protein kinase (AMPK) in cell and animal models.